Titanium dioxide (TiO2) is a widely used material in various products, including cosmetics, food additives, and medical devices. However, its small size (nanoscale) has raised concerns about its potential impacts on human health and the environment. One area of concern is the effect of Nanosized TiO2 on the female reproductive system, particularly the ovaries. The purpose of this study is to look at how isoniazid-treated NMRI mice’s ovarian tissue alters in response to Nanosized titanium dioxide (nano-TiO2) treatment. The 50 adult female mice used in this research were split into five groups of 10 at random. The experimental groups included the control group (no medication), sham group (0.5 mg/kg of normal saline), first experimental group (45 mg/kg isoniazid), second experimental group (45 mg/kg isoniazid and 0.5 mg/kg nano-TiO2), and the third experimental group (45 mg/kg isoniazid and 0.45 mg/kg nano-TiO2). All injections were given for 20 days. After that, the ovarian tissue from each animal was isolated and put in an 10% formalin solution before tissue analyses were carried out using hematoxylin and eosin (H&E) stain. In comparison to the control group, there was a reduction in the quantity of corpus luteum and secondary follicles in all experimental groups. In comparison to the first experimental group, there is a significant increase in the number of unilaminar primary follicles in the rest of the experimental groups. The damaging effects of isoniazid on ovarian tissue can be lessened by using nanoparticles in small amounts.

The preparation of nano-sized TiO2 by titanium tetraisopropoxide (Ti (OiPr)4) via sol-gel method using acid as a catalyst is investigated and the optimized conditions concerning the proportional amount of acid, water, alcohol is established by XRD and SEM. The effect of calcination temperature on phase transformation of TiO2 (rutile, anatase and brookite) was determined by XRD. The smallest grain size of TiO2 powder we have obtained is 25 nm for anatase at 400oC by controlling the acidity and the mole ratio of starting materials.

This review discusses recent developments in the field of Nanosized biomaterials and their use in tissue regeneration approaches. The aim is to provide an overview of the research focused on nanoparticle-based strategies to stimulate regeneration. In particular, nanoparticles improve the regenerative capabilities of biomaterials offering ways to control surface and mechanical properties. Moreover, incorporation of nanoparticles within biomaterials increases cellular adhesion, differentiation and integration of stem cells into the surrounding environment. Finally, the drug delivery capabilities of nanoparticles offer additional possibilities to increase the biological performance of biomaterials. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

The effect of three commercial types of titanium dioxide (TiO2) with primary particle sizes of 20 to 50 nm have been used for different sunscreens formulations. The efficiency of these sunscreens formulations, such as Sun Protection Factor (SPF), UVAPF and critical wavelength (λc) were tested. Oil/water creams with 5%, 10%, and 20% concentrations of each type of TiO2 were prepared, and SPF, UVAPF and λc were measured using both in vitro and in vivo methods. Because the samples have been aggregate and made the agglomerations, the milling and hemogenation methods have been used for decrease size of particles. In vitro analysis demonstrated that submicron-sized TiO2 cream had a lower SPF value than Nanosized TiO2 formulations of the same concentration. In vivo experiments confirmed this result, and a strong correlation between in vitro and in vivo measurements was observed. Furthermore, the SPF values of Nanosized TiO2 sunscreen were concentration-dependent in the range of 5% to 20%. Scanning electron microscopy results indicate that the higher SPF of Nanosized TiO2 formulations may be due to the formation of multilayer agglomerates by small particles at nano-scales, leading to a reduced void space between particles and a more efficient barrier to protect skin from sunlight.

In this paper we describe a facile method for the synthesis of Cu2O nanoparticles by reduction of Fehling's solution, using glucose as reducing agent. Copper sulfate is used as a precursor with potassium sodium tartarate in an alkaline media to produce Fehling's solution. The precipitation of Cu2O nanoparticles from this solution in the presence of glucose was controlled by addition of SLES or Triton-X 100 as surfactants. The reactions have been carried out at 60°C with high repeatability. The purification process of the Cu2O product does not require expensive methods, since a solid product is obtained from a reaction in liquid phase. The resulting Cu2O nanoparticles were characterized by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray spectroscopy (EDX), Transmission Electron Microscopy (TEM) and Fourier-transform infrared (FTIR) spectroscopy.